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Due to the increased risk of myopathyincluding rhabdomyolysisparticularly during the first year of treatmentuse of the 10/80-mg dose of VYTORIN should be restricted to patients who have been taking VYTORIN 10/80 mg chronicallye.gfor 12 months or morewithout evidence of muscle toxicitysee WARNINGS AND PRECAUTIONS

There have been rare postmarketing reports of cognitive impairmente.gmemory lossforgetfulnessamnesiamemory impairmentconfusionassociated with statin useThese cognitive issues have been reported for all statinsThe reports are generally nonseriousand reversible upon statin discontinuationwith variable times to symptom onset1 day to yearsand symptom resolutionmedian of 3 weeks

24Chan MHMak TWChiu RWChow CCChan IHLam CWSimvastatin increases serum osteocalcin concentration in patients treated for hypercholesterolaemiaJ Clin Endocrinol Metab 8620014556-9.

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